About the initial response of Sam and Sera to Brit's disability. Without the specific text or story, we must consider common narrative patterns for such situations.

• A. They accept it and focus on helping him become independent. This suggests a positive and adaptive response, often developed over time.
• B. They deny it and try various cures to make him "normal". This is a common initial reaction to a difficult diagnosis, reflecting shock, denial, and a desire to change the situation.
• C. They send him to a special school for disabled children. This is a practical action, which might occur after some processing, but doesn't necessarily describe the initial emotional response.
• D. They encourage him to pursue a medical career. This is a long-term plan and not typically an initial reaction to the onset of a disability.

Based on common human reactions and narrative portrayals of parents dealing with a child's disability, an initial phase of denial and seeking ways to "fix" the situation is frequently depicted before acceptance or adaptive strategies are adopted.

The most fitting initial response among the choices is B.

The final answer is $\boxed{\text{B}}$