When does the second heart sound occur in the ventricular pressure-volume relationship?

Question 1

Step 1: Determine the stroke volume (SV) from the pressure-volume diagram.
SV is the difference between end-diastolic volume (EDV at point B) and end-systolic volume (ESV at point A).
From the diagram:
$ESV = 50~mL, \quad EDV = 150~mL$
$SV = EDV - ESV = 150~mL - 50~mL = 100~mL/beat$

Step 2: Calculate cardiac output (CO).
Heart rate (HR) = $70~\mathrm{beats/min}$.
$CO = SV \times HR = 100~mL/beat \times 70~beats/min = 7000~mL/min$

Answer: 7000 mL/min (E)
7000

Question 2
The second heart sound (S2) is caused by closure of the aortic valve at the end of ejection (point D) and start of isovolumetric relaxation.
This occurs between point D and point A.

Answer: Between point D and point A (D)
D