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The female parent has Blood group O, so her genotype is ii. She passes an i allele to all her offspring.
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1.5.1
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a) W: The female parent has Blood group O, so her genotype is . She passes an allele to all her offspring. One child has Blood group A, meaning its genotype is . This child received from W. Another child has Blood group B, meaning its genotype is . This child received from W. Therefore, W must possess both and alleles. The genotype of W is .
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b) X: The male parent has Blood group A. Since his mother is Blood group O () and his father is W (), his genotype must be . This male parent and X have a child with Blood group O, whose genotype is . For the child to be , it must have received an allele from the father () and an allele from the mother (X). Therefore, X must carry at least one allele. The possible genotypes for X that include an allele are .
1.5.2
Haemophilia is an X-linked recessive disorder. Males have one X and one Y chromosome. If their single X chromosome carries the recessive allele for haemophilia, they will express the disorder because there is no dominant allele on the Y chromosome to mask it. Females have two X chromosomes, so they typically need two copies of the recessive allele to be affected; if they have one recessive and one dominant allele, they are usually just carriers.
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