Here are the answers to your questions:
2.4.1 An autosomal recessive condition means that an individual must inherit two copies of the recessive allele (one from each parent) to express the trait or disorder. Individuals with only one copy of the recessive allele are carriers and do not show the trait.
2.4.2 The letter of the child who is likely to die in the F2 generation is:
H
2.4.3
Step 1: Identify the genotype of child H.
Child H is affected by Leigh syndrome, which is an autosomal recessive disorder. Therefore, child H's genotype must be homozygous recessive, 'bb'.
Step 2: Determine the genotypes of H's parents.
Child H inherited one 'b' allele from each parent. H's parents are C (unaffected male) and D (unaffected female). Since they are unaffected but passed on a 'b' allele, both C and D must be heterozygous carriers with the genotype 'Bb'.
Step 3: Describe the inheritance.
Child H became affected because they inherited one recessive allele 'b' from their father (C) and another recessive allele 'b' from their mother (D). The presence of two recessive alleles (bb) resulted in the expression of Leigh syndrome.
2.4.4 The law of Mendel's that exists in the phenotypes of individuals K, L, and M is:
LawofDominance
2.4.5
Step 1: Determine the genotypes of K, L, and M.
Individuals K, L, and M are the offspring of G (affected male) and F (unaffected female). Since G is affected, his genotype is 'bb'. Since K, L, and M are unaffected, they must have at least one dominant allele 'B'. They inherited one 'b' allele from their father G. Therefore, they must have inherited a dominant 'B' allele from their mother F, making their genotype 'Bb'.
Step 2: Explain the Law of Dominance in this context.
The Law of Dominance states that in a heterozygote (like K, L, and M with genotype 'Bb'), the dominant allele (B) will completely mask the expression of the recessive allele (b). Even though K, L, and M carry the recessive allele for Leigh syndrome, they do not show the symptoms because the dominant allele for being unaffected is present and expressed.
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