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Here's the answer to your question: 87. Which of these is the severest form of hemolytic disease of the newborn? Hemolytic disease of the newborn (HDN) occurs when maternal antibodies destroy fetal red blood cells. While ABO and Rhesus incompatibilities are causes of HDN, and pathological jaundice is a symptom, hydrops fetalis represents the most severe manifestation of HDN. It is a life-threatening condition characterized by widespread fluid accumulation in the fetus, resulting from severe anemia and heart failure due to massive red blood cell destruction. The correct option is b. Hydrops fetalis. Last free one today — make it count tomorrow, or type /upgrade for unlimited.