What are the characteristics and advantages of ophthalmic inserts and intraocular dosage forms, and what are common preservatives and roles of viscosity in ophthalmic solutions?

You're on a roll — here are the answers to the questions from the image: 14. Ophthalmic inserts are usually: The correct option is B) Sterile solid or semisolid preparations for insertion into the conjunctival sac. Ophthalmic inserts are designed to be sterile and provide a sustained release of medication. 15. What is a main advantage of ophthalmic inserts? The correct option is E) Prolonged drug release and reduced number of administrations. Ophthalmic inserts are designed to provide a slow, continuous release of medication, reducing the frequency of dosing. 16. Intraocular dosage forms are generally introduced: The correct option is C) Into the interior structures of the eye during ocular surgery. Intraocular dosage forms are administered directly into the eye, often during surgical procedures, to treat conditions affecting the inner eye. 17. Which of the following drugs is commonly used as a preservative in ophthalmic solutions? The correct option is A) Benzalkonium chloride. Benzalkonium chloride is a widely used preservative in ophthalmic preparations due to its broad-spectrum antimicrobial activity. 18. What is the role of viscosity in ophthalmic solutions? The correct option is B) To increase retention time on the eye surface. Increasing the viscosity of ophthalmic solutions helps the drug stay on the eye surface longer, improving contact time and absorption. 19. Which drug may be used as a diagnostic agent in ophthalmic application? The correct option is B) Sodium fluorescein. Sodium fluorescein is commonly used as a diagnostic agent to detect corneal abrasions or foreign bodies in the eye. 20. Lacrisert, an example of an ophthalmic insert, is composed mainly of: The correct option is B) Hydroxypropyl cellulose. Lacrisert is a sterile, rod-shaped ophthalmic insert made of hydroxypropyl cellulose, used to treat dry eye syndrome. SECTION B: Short answer questions 1. Why do clean rooms have Barriers or isolators in the formulation section? (1 mark) Clean rooms have barriers or isolators to maintain sterility and prevent contamination of the product and manufacturing environment, especially for sterile preparations like injectables. 2. Outline two (2) methods through which water for injection is produced? (3 marks) Two methods for producing Water for Injection (WFI) are: Distillation*: Water is boiled, and the resulting steam is condensed, leaving impurities behind. Reverse Osmosis (RO)*: Water is forced under pressure through a semi-permeable membrane that removes ions, molecules, and larger particles. 3. What are some of the measures taken during gowning and disgowning into prevent contamination into the clean room? (5 marks) Measures taken during gowning and disgowning to prevent contamination include: Sequential donning*: Gowning is performed in a specific order, typically from dirtiest to cleanest garments (e.g., shoe covers, hairnet, mask, jumpsuit, gloves). Air showers/airlocks*: Personnel pass through these to remove particulate matter before entering the clean room. Hand sanitization*: Thorough hand washing and sanitizing with appropriate disinfectants before gloving. Controlled environment*: Gowning rooms are often classified clean areas themselves, with controlled airflow and pressure differentials. Disgowning protocol*: A specific sequence for removing garments to prevent shedding contaminants into the clean environment or spreading them outside. SECTION C: Definitions of liquid dosage form Here are definitions for the listed liquid dosage forms: 1. Syrup: A concentrated aqueous solution of sugar or a sugar substitute, with or without added flavoring agents and medicinal substances. 2. Elixir: A clear, sweetened hydroalcoholic solution intended for oral use, usually containing flavoring agents and active medicinal ingredients. 3. Tinctures: Alcoholic or hydroalcoholic solutions prepared from vegetable materials or chemical substances, typically containing high concentrations of alcohol. 4. Douche: An aqueous solution intended for cleansing a body cavity or surface, often applied with a syringe or similar device. 5. Liniment: An alcoholic or oily solution or emulsion intended for external application to the skin, usually with rubbing, to relieve pain or stiffness. Drop the next question.