a) A sex-linked characteristic is a trait whose gene is located on one of the sex chromosomes (X or Y), rather than on an autosome. These traits often show different patterns of inheritance in males and females.
b)
i)
The problem states that haemophilia is due to a recessive allele Xh, and XH is for normal blood clotting. A normal couple had a haemophilic son (XhY).
- Since the son is haemophilic (XhY), he inherited the Y chromosome from his father and the Xh chromosome from his mother.
- The father is normal, so his genotype must be XHY.
- The mother is normal but passed on an Xh allele to her son, so she must be a carrier. Her genotype must be XHXh.
Genotypes:
Father: XHY
Mother: XHXh
ii)
To show how a haemophilic son could have been born, we use a genetic diagram (Punnett square) with the parents' genotypes: Father (XHY) and Mother (XHXh).
Parental Genotypes:
Father: XHY
Mother: XHXh
Gametes:
Father: XH, Y
Mother: XH, Xh
Punnett Square:
GametesXHYXHXHXHXHYXhXHXhXhY
Offspring Genotypes and Phenotypes:
- XHXH: Normal female
- XHXh: Normal female (carrier)
- XHY: Normal male
- XhY: Haemophilic male
The genetic diagram shows that there is a 25% chance for the couple to have a haemophilic son (XhY).