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The problem states that haemophilia is due to a recessive allele X^h, and X^H is for normal blood clotting. A normal couple had a haemophilic son (X^hY).

Biology

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Answer

b(i)

XHYX^HY

XHXhX^HX^h

a) A sex-linked characteristic is a trait whose gene is located on one of the sex chromosomes (X or Y), rather than on an autosome. These traits often show different patterns of inheritance in males and females.

b)

i)
The problem states that haemophilia is due to a recessive allele XhX^h, and XHX^H is for normal blood clotting. A normal couple had a haemophilic son (XhYX^hY).

  • Since the son is haemophilic (XhYX^hY), he inherited the YY chromosome from his father and the XhX^h chromosome from his mother.
  • The father is normal, so his genotype must be XHYX^HY.
  • The mother is normal but passed on an XhX^h allele to her son, so she must be a carrier. Her genotype must be XHXhX^HX^h.

Genotypes:
Father: XHY\boxed{X^HY}
Mother: XHXh\boxed{X^HX^h}

ii)
To show how a haemophilic son could have been born, we use a genetic diagram (Punnett square) with the parents' genotypes: Father (XHYX^HY) and Mother (XHXhX^HX^h).

Parental Genotypes:
Father: XHYX^HY
Mother: XHXhX^HX^h

Gametes:
Father: XHX^H, YY
Mother: XHX^H, XhX^h

Punnett Square:

GametesXHXhXHXHXHXHXhYXHYXhY\begin{array}{|c|c|c|} \hline \textbf{Gametes} & X^H & X^h \\ \hline X^H & X^HX^H & X^HX^h \\ \hline Y & X^HY & X^hY \\ \hline \end{array}

Offspring Genotypes and Phenotypes:

  • XHXHX^HX^H: Normal female
  • XHXhX^HX^h: Normal female (carrier)
  • XHYX^HY: Normal male
  • XhYX^hY: Haemophilic male

The genetic diagram shows that there is a 25% chance for the couple to have a haemophilic son (XhYX^hY).

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