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We are given the density ($\rho$) and the volume (V) of the substance, and we need to find its mass (m).
$\rho = 1.25 \text{ g/cm}^3$
$V = 250 \text{ cm}^3$
$m = ?$

The relationship between density, mass, and volume is given by:
$\rho = \frac{m}{V}$

To find the mass, we can multiply the density by the volume:
$m = \rho \times V$

$m = 1.25 \text{ g/cm}^3 \times 250 \text{ cm}^3$
$m = 312.5 \text{ g}$