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Using a metabolic pathway only, describe the biosynthesis of Serine amino acid.

Biology

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SECTION A

1a. Using a metabolic pathway only, describe the biosynthesis of Serine amino acid.
Serine is synthesized from 3-phosphoglycerate, an intermediate of glycolysis.

  1. 3-Phosphoglycerate dehydrogenase* oxidizes 3-phosphoglycerate to 3-phosphohydroxypyruvate.

    This reaction uses NAD+\text{NAD}^+ as a cofactor.

  2. Phosphoserine aminotransferase* transfers an amino group from glutamate to 3-phosphohydroxypyruvate, forming phosphoserine and α\alpha-ketoglutarate.

  3. Phosphoserine phosphatase* hydrolyzes phosphoserine to

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