Oxidation reaction of primary alcohol to aldehyde and also carboxylic acid. Send a graphical explanation

Chemistry

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Here is a graphical explanation of the oxidation of a primary alcohol to an aldehyde and then to a carboxylic acid:

R-CH2OH→Mild oxidizing agent (e.g., PCC)R-CHO→Strong oxidizing agent (e.g., K2Cr2O7/H+)R-COOH\text{R-CH}_2\text{OH} \quad \xrightarrow{\text{Mild oxidizing agent (e.g., PCC)}} \quad \text{R-CHO} \quad \xrightarrow{\text{Strong oxidizing agent (e.g., K}_2\text{Cr}_2\text{O}_7\text{/H}^+)} \quad \text{R-COOH}
  • Primary Alcohol to Aldehyde: A primary alcohol (R-CH2OH\text{R-CH}_2\text{OH}) can be oxidized to an aldehyde (R-CHO\text{R-CHO}) using a mild oxidizing agent. Examples include Pyridinium Chlorochromate (PCC) in dichloromethane. This reaction stops at the aldehyde stage because PCC is a selective oxidant and the reaction is often carried out under anhydrous conditions.

  • Aldehyde to Carboxylic Acid: The aldehyde (R-CHO\text{R-CHO}) can then be further oxidized to a carboxylic acid (R-COOH\text{R-COOH}) using a strong oxidizing agent. Examples include potassium dichromate (K2Cr2O7\text{K}_2\text{Cr}_2\text{O}_7) in acidic conditions (H+\text{H}^+), potassium permanganate (KMnO4\text{KMnO}_4), or chromic acid (CrO3/H2SO4\text{CrO}_3/\text{H}_2\text{SO}_4).

  • Primary Alcohol to Carboxylic Acid (Direct): A primary alcohol can also be directly oxidized to a carboxylic acid using a strong oxidizing agent, bypassing the isolation of the aldehyde intermediate.

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