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Using the provided pedigree, determine the genotype of offspring 1 and the possible genotypes of offspring from a carrier woman and a hemophiliac man.
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3 partsStep-by-step solution
7 stepsPart b· 3 steps
Identify offspring number 1 in the pedigree.
Offspring number 1 is a male, indicated by a square. The square is not shaded, which means he is a normal male according to the key.
Determine the genotypes of his parents.
Hemophilia is an X-linked recessive condition. is for non-hemophilia, is for hemophilia.
The mother of offspring 1 is a normal carrier female (circle with diagonal line), so her genotype is .
The father of offspring 1 is a normal male (unshaded square), so his genotype is .Determine the genotype of offspring number 1.
Offspring 1 is a male, so he inherits a chromosome from his father. He inherits an X chromosome from his mother. Since he is normal, he must have inherited the allele from his mother.
Therefore, the genotype of offspring number 1 is .The genotype of offspring number 1 is .
Part c
Determine the genotypes of the couple.
A carrier woman has genotype .
A hemophiliac man has genotype .Set up a Punnett square to determine the possible genotypes of their offspring.
The woman produces gametes and .
The man produces gametes and .Identify the genotypes of sons and hemophiliac sons.
From the Punnett square, the possible genotypes for sons are (normal son) and (hemophiliac son).
Calculate the probability of having a son who is hemophiliac.
There are 4 possible offspring genotypes, and 1 of them is (hemophiliac son).
The probability is .The probability that the couple will have a son who is hemophiliac is .
Part d
One defect of non-disjunction chromosomal mutation is Down syndrome. This condition is caused by an extra copy of chromosome 21 (Trisomy 21), which results from non-disjunction during meiosis.
Name one defect of non-disjunction chromosomal mutation: .
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