A physician prescribed ciproflaxin for a 15kg child to be taken twice daily for 7 days. You need to compound a suspension with a strength of 250mg/5ml. a. What's the required dose per administration. b. What is the total volume of suspension required c. How many 500mg tables are needed to compound this?

Chemistry

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Answers

3 parts
a

450 mg\text{450 mg}

b

126 mL\text{126 mL}

c

12.6 tablets\text{12.6 tablets}

Step-by-step solution

7 steps

To solve this problem, we need the prescribed dose per kilogram per day. Since it's not explicitly stated in your current question, I will assume the dose is 60 mg/kg/day60 \text{ mg/kg/day}, similar to the previous problem.

Given Information (with assumed dose):

  • Patient weight: 15 kg15 \text{ kg}
  • Assumed Dose: 60 mg/kg/day60 \text{ mg/kg/day}
  • Frequency: Twice daily (BID)
  • Duration: 7 days7 \text{ days}
  • Suspension strength: 250 mg/5 mL250 \text{ mg/5 mL}
  • Tablet strength: 500 mg/tablet500 \text{ mg/tablet}

Part a· 2 steps

What's the required dose per administration?

  1. Calculate the total daily dose.

    Total daily dose=Dose per kg per day×Patient weight\text{Total daily dose} = \text{Dose per kg per day} \times \text{Patient weight} Total daily dose=60 mg/kg/day×15 kg=900 mg/day\text{Total daily dose} = 60 \text{ mg/kg/day} \times 15 \text{ kg} = 900 \text{ mg/day}

  2. Calculate the dose per administration.

    Since the medication is taken twice daily (BID), there are 2 administrations per day.

    Dose per administration=Total daily doseNumber of administrations per day\text{Dose per administration} = \frac{\text{Total daily dose}}{\text{Number of administrations per day}} Dose per administration=900 mg/day2 administrations/day=450 mg/administration\text{Dose per administration} = \frac{900 \text{ mg/day}}{2 \text{ administrations/day}} = 450 \text{ mg/administration}

    The required dose per administration is 450 mg\boxed{\text{450 mg}}.

Part b

126 mL\text{126 mL}

What is the total volume of suspension required?

  1. Calculate the total amount of drug needed for the entire 7-day course.

    Total drug needed=Total daily dose×Duration\text{Total drug needed} = \text{Total daily dose} \times \text{Duration} Total drug needed=900 mg/day×7 days=6300 mg\text{Total drug needed} = 900 \text{ mg/day} \times 7 \text{ days} = 6300 \text{ mg}

  2. Determine the concentration of the suspension in mg/mL.

    Suspension concentration=250 mg5 mL=50 mg/mL\text{Suspension concentration} = \frac{250 \text{ mg}}{5 \text{ mL}} = 50 \text{ mg/mL}

  3. Calculate the total volume of suspension required.

    Total volume of suspension=Total drug neededSuspension concentration\text{Total volume of suspension} = \frac{\text{Total drug needed}}{\text{Suspension concentration}} Total volume of suspension=6300 mg50 mg/mL=126 mL\text{Total volume of suspension} = \frac{6300 \text{ mg}}{50 \text{ mg/mL}} = 126 \text{ mL}

    The total volume of suspension required is 126 mL\boxed{\text{126 mL}}.

Part c

12.6 tablets\text{12.6 tablets}

How many 500 mg tablets are needed to compound this?

  1. Use the total amount of drug needed for the entire course, calculated in part b.

    Total drug needed=6300 mg\text{Total drug needed} = 6300 \text{ mg}

  2. Calculate the number of tablets required based on the tablet strength.

    Number of tablets=Total drug neededTablet strength\text{Number of tablets} = \frac{\text{Total drug needed}}{\text{Tablet strength}} Number of tablets=6300 mg500 mg/tablet=12.6 tablets\text{Number of tablets} = \frac{6300 \text{ mg}}{500 \text{ mg/tablet}} = 12.6 \text{ tablets}

    The number of 500 mg tablets needed to compound the suspension is 12.6 tablets\boxed{\text{12.6 tablets}}.

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