A 10 kg child requires a dose of 60 mg/kg/day of a medication, administered twice daily. The available suspension is 250 mg/5 mL. Calculate the dose per administration and the total volume of suspensi

Here's the solution to the problem: Given Information: Patient weight: 10 kg Dose: 60 mg/kg/day Frequency: Twice daily (BID) Duration: 7 days Suspension strength: 250 mg/5 mL Tablet strength: 500 mg/tablet --- a) What is the required dose per administration? Step 1: Calculate the total daily dose. Total daily dose = Dose per kg per day × Patient weight Total daily dose = 60 mg/kg/day × 10 kg = 600 mg/day Step 2: Calculate the dose per administration. Since the medication is taken twice daily (BID), there are 2 administrations per day. Dose per administration = Total daily doseNumber of administrations per day Dose per administration = 600 mg/day2 administrations/day = 300 mg/administration The required dose per administration is 300 mg. --- b) What is the total volume of suspension required? Step 1: Calculate the total amount of drug needed for the entire 7-day course. Total drug needed = Total daily dose × Duration Total drug needed = 600 mg/day × 7 days = 4200 mg Step 2: Determine the concentration of the suspension in mg/mL. Suspension concentration = 250 mg5 mL = 50 mg/mL Step 3: Calculate the total volume of suspension required. Total volume of suspension = Total drug neededSuspension concentration Total volume of suspension = 4200 mg50 mg/mL = 84 mL The total volume of suspension required is 84 mL. --- c) How many 500 mg tablets are needed to compound the suspension? Step 1: Use the total amount of drug needed for the entire course, calculated in part b. Total drug needed = 4200 mg Step 2: Calculate the number of tablets required based on the tablet strength. Number of tablets = Total drug neededTablet strength Number of tablets = 4200 mg500 mg/tablet = 8.4 tablets The number of 500 mg tablets needed to compound the suspension is 8.4 tablets.