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Calculate the amphotericin infusion dose, volume, and rate for a patient weighing 89 kg, prescribed 250 µg/kg, with a maximum concentration of 200 µg/mL, to be infused over 2.5 hours.
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Here are the calculations for the amphotericin infusion:
1. Calculate the dose of amphotericin required by the patient.
Calculate the total dose based on patient weight and prescribed dose per kilogram.
Convert the total dose from micrograms to milligrams.
The dose of amphotericin required by the patient is .
2. Calculate the volume of IV solution required by the patient if the solution contains the maximum concentration.
Use the total dose (in micrograms) and the maximum allowed concentration to find the volume.
The volume of IV solution required by the patient is .
3. If the solution has to be delivered in 2.5 hours, what is the rate in mL/minute?
Convert the infusion time from hours to minutes.
Calculate the infusion rate using the volume from the previous step and the time in minutes.
The rate of infusion is approximately .
4. If a 50mg vial is used to prepare the IV solution, what is the total volume of the solution prepared?
Convert the amount of drug in the vial from milligrams to micrograms.
Calculate the total volume of the solution prepared using the amount of drug in the vial and the maximum allowed concentration.
The total volume of the solution prepared from a 50mg vial at the maximum concentration is .
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