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Calculate the amphotericin infusion dose, volume, and rate for a patient weighing 89 kg, prescribed 250 µg/kg, with a maximum concentration of 200 µg/mL, to be infused over 2.5 hours.

Chemistry

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Here are the calculations for the amphotericin infusion:

1. Calculate the dose of amphotericin required by the patient.

  1. Calculate the total dose based on patient weight and prescribed dose per kilogram.

    Total dose=89 kg×250μgkg=22250 μg\text{Total dose} = 89\text{ kg} \times 250 \frac{\mu\text{g}}{\text{kg}} = 22250\text{ }\mu\text{g}
  2. Convert the total dose from micrograms to milligrams.

    Total dose=22250 μg×1 mg1000 μg=22.25 mg\text{Total dose} = 22250\text{ }\mu\text{g} \times \frac{1\text{ mg}}{1000\text{ }\mu\text{g}} = 22.25\text{ mg}

    The dose of amphotericin required by the patient is 22.25 mg\boxed{\textbf{22.25 mg}}.

    2. Calculate the volume of IV solution required by the patient if the solution contains the maximum concentration.

  3. Use the total dose (in micrograms) and the maximum allowed concentration to find the volume.

    Volume=Total doseConcentration=22250 μg200μgmL\text{Volume} = \frac{\text{Total dose}}{\text{Concentration}} = \frac{22250\text{ }\mu\text{g}}{200 \frac{\mu\text{g}}{\text{mL}}} Volume=111.25 mL\text{Volume} = 111.25\text{ mL}

    The volume of IV solution required by the patient is 111.25 mL\boxed{\textbf{111.25 mL}}.

    3. If the solution has to be delivered in 2.5 hours, what is the rate in mL/minute?

  4. Convert the infusion time from hours to minutes.

    Time in minutes=2.5 hours×60minhour=150 minutes\text{Time in minutes} = 2.5\text{ hours} \times 60 \frac{\text{min}}{\text{hour}} = 150\text{ minutes}
  5. Calculate the infusion rate using the volume from the previous step and the time in minutes.

    Rate=VolumeTime=111.25 mL150 min\text{Rate} = \frac{\text{Volume}}{\text{Time}} = \frac{111.25\text{ mL}}{150\text{ min}} Rate≈0.7417mLmin\text{Rate} \approx 0.7417 \frac{\text{mL}}{\text{min}}

    The rate of infusion is approximately 0.74 mL/minute\boxed{\textbf{0.74 mL/minute}}.

    4. If a 50mg vial is used to prepare the IV solution, what is the total volume of the solution prepared?

  6. Convert the amount of drug in the vial from milligrams to micrograms.

    Amount of drug=50 mg×1000μgmg=50000 μg\text{Amount of drug} = 50\text{ mg} \times 1000 \frac{\mu\text{g}}{\text{mg}} = 50000\text{ }\mu\text{g}
  7. Calculate the total volume of the solution prepared using the amount of drug in the vial and the maximum allowed concentration.

    Total volume=Amount of drugConcentration=50000 μg200μgmL\text{Total volume} = \frac{\text{Amount of drug}}{\text{Concentration}} = \frac{50000\text{ }\mu\text{g}}{200 \frac{\mu\text{g}}{\text{mL}}} Total volume=250 mL\text{Total volume} = 250\text{ mL}

    The total volume of the solution prepared from a 50mg vial at the maximum concentration is 250 mL\boxed{\textbf{250 mL}}.

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