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In Class: Benzene -> Chlorobenzene. On Exam: Benzene -> complex molecule with stereocenters. What reagents are missing?
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2 stepsHere are the reactions:
In Class:
Identify the starting material and product.
The starting material is benzene, and the product is chlorobenzene. This is a halogenation reaction.
Determine the reagents for the halogenation of benzene.
Benzene undergoes electrophilic aromatic substitution with chlorine in the presence of a Lewis acid catalyst.
The reagents are chlorine gas () and iron(III) chloride () or aluminum chloride ().The reaction is:
The reagents for the "in Class" reaction are .
On Exam:
The "On Exam" reaction shows benzene being converted into a highly complex polycyclic molecule with multiple functional groups (ketone, amine) and chiral centers. This type of transformation from benzene is not a single-step reaction. It represents a multi-step synthesis, often involving many different reaction types (e.g., Friedel-Crafts reactions, reductions, oxidations, cyclizations, stereoselective steps) to build such a complex structure. It is a challenging synthetic problem, not a simple one-step conversion.
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