What do you understand by the term, "Percolation Segregation" and mention four approaches to minimise segregation

VICMMANUEL👻⭐, let's get this done. Section I 4. What do you understand by the term, "Percolation Segregation" and mention four approaches to minimise segregation Percolation segregation is a type of particle segregation that happens in powder mixtures where smaller particles move downwards, sifting through the gaps between larger particles. This usually occurs when a powder bed is vibrated, agitated, or moved. This leads to an uneven distribution of different particle sizes within the mixture, which can negatively affect the uniformity and quality of pharmaceutical products. Four approaches to minimize segregation: • Reduce particle size differences: Make the particle sizes in the mixture as uniform as possible to prevent smaller particles from sifting through larger ones. • Granulation: Convert fine powders into larger, more consistent granules. This reduces the tendency for segregation and improves how the powder flows. • Add a binding agent: Use a small amount of liquid or solid binder to make particles stick together, forming clumps that are less likely to segregate. • Minimize handling and vibration: Reduce the number of times the powder mixture is transferred and minimize any shaking or vibration during storage, transport, and processing. • Ordered mixing: Attach fine particles to the surface of larger particles, creating a more stable mixture that is less prone to segregation. Got more? Send 'em!