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In a cross between two individuals with genotypes for haemophilia X^HX^h x X^HY, the chances of having a haemophilic son is

Biology

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Step-by-step solution

5 steps

To determine the chances of having a haemophilic son, we need to perform a genetic cross using the given parental genotypes. Haemophilia is an X-linked recessive disorder.

  1. Identify the genotypes of the parents.

    The problem states the genotypes are XhXhX^hX^h and XHYX^HY.

    • Female parent: XhXhX^hX^h (haemophilic female)
    • Male parent: XHYX^HY (normal male)
  2. Set up a Punnett square for the cross.

    The female parent can produce only XhX^h gametes.
    The male parent can produce XHX^H and YY gametes.

    GametesXHYXhXHXhXhYXhXHXhXhY\begin{array}{|c|c|c|} \hline \text{Gametes} & X^H & Y \\ \hline X^h & X^HX^h & X^hY \\ \hline X^h & X^HX^h & X^hY \\ \hline \end{array}
  3. Determine the genotypes and phenotypes of the offspring.

    From the Punnett square, the possible offspring genotypes are:

    • XHXhX^HX^h: Carrier female (not haemophilic)
    • XhYX^hY: Haemophilic male
  4. Calculate the probability of having a haemophilic son.

    Out of 4 possible offspring combinations, 2 are XhYX^hY (haemophilic sons).
    The probability of having a haemophilic son is 24=12\frac{2}{4} = \frac{1}{2}.

  5. Convert the probability to a percentage.

    12×100%=50%\frac{1}{2} \times 100\% = 50\%

    The chances of having a haemophilic son are 50%.

    The final answer is C. 50%\boxed{\text{C. 50\%}}.

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