Fatty change refers to the accumulation of excess fat or lipids within cells. This is a type of reversible cell injury. Here's a more detailed explanation: What happens: Normally, cells process fats (lipids) for energy or to build cell structures. In fatty change, the cell's ability to metabolize or export these fats is disrupted. This can happen due to various reasons, such as: Toxins*: Like alcohol, which damages liver cells. Hypoxia* (lack of oxygen): This impairs the cell's energy production needed for fat metabolism. Nutritional imbalances*: Severe malnutrition or obesity can affect fat processing. Certain diseases*: Like diabetes or certain genetic disorders. Where it's seen: It's most commonly observed in cells that are heavily involved in fat metabolism, particularly liver cells (hepatocytes) and heart muscle cells* (myocytes). Appearance: Under a microscope, the affected cells appear to have small or large droplets of fat within their cytoplasm. Reversibility: If the underlying cause is removed or corrected, the cell can often clear the excess fat and return to normal. However, if the stress continues, it can lead to more severe cell damage and eventually cell death.